Additionally, the urinary albumin-to-creatinine ratio, an indicator of proteinuria severity, showed a decreasing trend in rebamipide-treated mice compared to vehicle-treated mice ( Figure 3 C).
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Rebamipide Attenuates Lupus Nephritis by Enhancing Antioxidative Defense in Podocytes: Evidence from a Lupus-Prone Mouse Model.
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In vitro treatment with rebamipide showed a trend toward restoring the expression of these proteins, with the most prominent effect observed in Synaptopodin, consistent with the in vivo results from lupus-prone mice ( Figure 6 A).
Kidney tissues from MRL/ lpr mice exhibited an increasing trend in 4-HNE expression compared to those from MRL/MpJ mice, which served as healthy controls ( Figure 5 A).