An Experimental Rat Model for Simultaneous Induction of Peripheral Neuropathy and Myelotoxicity by Docetaxel Administration: Evaluating the Protective Role of Dimethyl Fumarate.

An alternative regimen with additional pre-administered doses of dimethyl fumarate showed a trend toward neutropenia attenuation and suggested an interesting inhibition of docetaxel-induced rat vibrissae loss.

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While significant protection against neutropenia was not observed, a positive trend in neutrophil recovery was noted with increased dimethyl fumarate dosing ( Figure 6 c), warranting further investigation into larger-dose regimens or a higher number of doses before docetaxel.

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