A Multicentre, Double-Blind, Randomised, Non-Inferiority Trial of a Novel Single-Injection Intra-Articular HMDA-Cross-Linked Hyaluronate Gel for Knee Osteoarthritis.

Although changes were minimal and did not reach statistical significance within or between groups across any visit ( Table 2 and Table S4 ), a numerically greater improvement in the range of motion (both extension and flexion) was observed in the HMDA-HA group through Week 36 ( Figure S1 , Table S4 ).

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