Association of microtubule destabilization with platelet yields in terminally differentiating hiPSC-derived megakaryocyte lines.

While this effect did not reach statistical significance compared to the control group or the 10 nM group, the 10 μM dose group was the only experimental group that included mice that continued to bleed for over 600 seconds ( Fig 5C ), in line with our in vitro data showing a slightly reduced functionality of iPSC-platelets produced under these conditions ( Fig 4B ).

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