Molecular Crosstalk Between SIRT1, Wnt/β-Catenin Signaling, and Inflammatory Pathways in Renal Transplant Rejection: Role of miRNAs, lncRNAs, IL-1, IL-6, and Tubulointerstitial Inflammation.

An increase in IL6 levels was also observed in the tubulitis group; although the raw p -value was significant, the FDR-adjusted value approached but did not reach statistical significance (raw p = 0.046; FDR p = 0.069).

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The association between WNT1 and SIRT6 was highly significant in terms of both the original p -value (<0.001) and the FDR-adjusted p -value (<0.001) ( Table 3 ; Supplementary Tables S1 and S2 ; Figure 1 ).

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