Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial.

When changes in gene expression were examined across all 18 subjects (all three treatment arms), the increase in NQO1 (3.3-fold) expression was highly significant by one-sample mean comparison test (t = 6.4; p < 0.0001) ( Figure 6 A and Table 2 ).

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Although the change of most individual markers did not reach statistical significance, the functionally grouped markers showed highly significant differences from the baseline [ 12 ].

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