Universal Bacterium-Vectored COVID-19 Vaccine Expressing Early SARS-CoV-2 Conserved Proteins Cross-Protects Against Late Variants in Hamsters.

Of note, the addition of RdRp to the MN vaccine further reduced viral titers in oropharyngeal swabs after IN administration ( p < 0.05) and reduced histopathological scores in lungs after both IN and PO administration, although the differences in histopathological scores did not reach statistical significance ( Figure 2 d,e,h,i).

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