Contribution of CARD9 signaling to wound healing in skin promoted by topical administration of heat-killed <i>Enterococcus faecalis</i> strain KH2 and the involvement of Dectin-2.

As shown in Figures 3A–C , the proportion of Ly6C+MHCII− macrophages was significantly lower in heat-killed KH2-treated WT mice compared with vehicle-treated WT mice, and also showed a trend toward a lower proportion compared with heat-killed KH2-treated KO mice.

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On day 1, the number of neutrophils in heat-killed KH2-treated CARD9 KO mice showed a decreasing trend compared to heat-killed KH2-treated WT mice, with a significant reduction observed on day 3 ( Figure 2B ).

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