A significant trend across quartiles ( p for trend < 0.001) and a restricted cubic spline analysis indicating a non-linear relationship—with an inflection point at a UA/Cr value of 6.4 and a 95% CI delineated by a shaded region—reinforce the dose-dependent relationship between increasing UA/Cr levels and gallstone risk ( Figure 2 ).
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The association between serum uric acid to creatinine ratio and gallstones: National Health and Nutrition Examination Survey 2017-2020.
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