Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndrome

Although some Latin American countries show a decreasing trend in mortality rates, in others, the mortality continues to increase compared to more developed regions 3 .

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Other variants in the genes SORT1, ABCA1, APOE, APOA1, CXCL12 , and IFNG showed significant confidence intervals but did not reach statistical significance after multiple testing corrections ( supplementary table 4 ).

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We identified a highly significant association of genetic variants in the LPA and APOE genes with early acute coronary syndrome.

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