Effects of Proteinuria on Cerebral and Muscle Oxygenation and Microvascular Reactivity in Patients With Pre-Dialysis Chronic Kidney Disease: A Post-Hoc Analysis.

Conclusions In this exploratory analysis, CKD patients with proteinuria showed signs of attenuated cerebral oxygenation during a mild physical task and a possible trend toward modest impairments in skeletal muscle oxidative capacity and microvascular reactivity.

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During reperfusion, proteinuric patients showed a trend for reduced hyperemic response (although this was not statistically significant) compared to non-proteinuric patients (7.3 ± 4.0 vs. 8.5 ± 4.5, p=0.296).

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