The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.

All differences among and between groups were classified according to the P -value levels: P < 0.05 was considered statistically significant; P < 0.01 indicated a highly significant difference; P < 0.001 represented an extremely significant difference; and P < 0.0001 signified a very extremely significant difference.

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Additionally, the abundances of Adlerceutzia , Corynebacterium , Treponema , and Mucispirillum were also elevated in the HS + CUMS + PY group, even though the difference in abundance did not reach statistical significance ( Figure 11A ).

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