Replication stress responses in human lymphocytes change sex-specifically during aging.

Measurements of DNA replication tracks showed a trend to 1.2-fold elongation of IdU tracks in PBL from older female but not male donors, a situation expected for enhanced TLS or reduced fork stalling (Fig. 3D ).

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When we compared the mean viability curves of PBL from older individuals (>60 years) with the curves of PBL from the younger cohort (<60), we noticed a 3.3-fold, highly significant decrease of the average IC50 value for older versus young men, while viability curves for both older and young women were indistinguishable (Fig. 6A ).

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