Cell-Derived Epigenomic Markers of Chronic Stress Distinguish Breast Cancer Phenotypes.

Furthermore, both MRSs significantly differed across tumor stages in BRCA (with age and race: Cortisol-related p = 2.5×10 -3 , GR-specific p = 1.6×10 -3 ; with age, race, ethnicity, and therapy: Cortisol-related p = 1.4×10 -2 , GR-specific p = 9.6×10 -3 ) and showed a similar pattern that did not reach statistical significance in the smaller MPBC cohort (with age and race: Cortisol-related: p = 0.29, GR-specific: p = 0.35; with age, race, ethnicity, and therapy: Cortisol-related p = 0.62, GR-specific p = 0.84).

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