Temporal changes of the life and renal prognoses of patients with rapidly progressive glomerulonephritis in Japan, 1989-2019.

Cumulative survival at 24 months remained stable (periods 1989–1998, 1999–2001, 2002–2008, 2009–2011, 2012–2015, 2016–2019 were each 72.0%, 72.9%, 77.7%, 83.0%, 84.9%, 83.5%, p < 0.01), while renal survival showed a favorable trend in the most recent periods (there were each 68.7%, 75.4%, 76.7%, 73.4%, 78.2%, 78.4%, p < 0.01).

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The Cre levels at onset showed a decreasing trend compared to the earlier five time periods.

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Death from infection during the latest period was the lowest among all six of the periods, and similarly, death from infection was the lowest in the AAV patients; both of these showed a trend toward improvement over time.

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