C9orf72 deficiency impairs the autophagic response to aggregated TDP-25 and exacerbates TDP-25-mediated neurodegeneration in vivo.

Acta Neuropathol Commun · 2025 · PMC12205521 · PMID 40581653

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showed a trendno p-value reported

Biochemical analysis of total brain lysates showed a trend towards increased levels of p62 in both TDP-25-C9WT and TDP-25-C9KO mice compared to the respective EGFP-expressing control mice (Fig. 8 a, b).

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