Defining Non-small Cell Lung Cancer Tumor Microenvironment Changes at Primary and Acquired Immune Checkpoint Inhibitor Resistance Using Clinical and Real-World Data.

Cancer Res Commun · 2025 · PMC12207206 · PMID 40488300

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.5200

boldest claim

The sentences

showed a trendP value = 0.09so close (0.05 < p ≤ 0.1)

A similar trend was also observed in Tempus OS that IFNγ scores showed a trend of favorable OS outcomes only in PD-L1 high subgroups (HR = 0.63, P value = 0.09 for PD-L1 ≥50% vs.

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a numerical trendP value = 0.52not close (p > 0.1)

2C ), but a numerical trend was observed in the PD-L1 ≥50% subgroup (Kruskal–Wallis P value = 0.52).

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a mild trendno p-value reported

Of 25 patients, 13 experienced a switch in PD-L1 IHC class after ICI treatment, and there was a mild trend toward PD-L1 decrease.

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