Ciprofol Versus Propofol for Sedation in Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis in a Chinese Population.

Ciprofol was associated with a reduction in induction time (SMD: −0.65, 95% CI: −1.37 to 0.07, I 2 = 96%) and lower incidence of hypotension (RR: 0.79, 95% CI: 0.42 to 1.49, I 2 = 86%) and bradycardia (RR: 0.89, 95% CI: 0.61 to 1.29, I 2 = 33%), though these effects did not reach statistical significance. 5 Hung et al performed a systematic review and meta-analysis of 12 clinical trials evaluating ciprofol versus propofol for anesthesia induction and non-intensive care unit sedation. 7 Aggregated data showed non-significant intergroup differences in procedural success rates (RR: 1.00, 95% CI: 0.99 to 1.01, I 2 = 0%) and time-to-effect metrics (MD: 7.95 s, 95% CI: −1.09 to 16.99, I 2 = 97%), with the latter demonstrating substantial heterogeneity.

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Thus, the risk of spurious results is likely to be significant.

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