Somatic mutations and outcomes in chronic myeloid leukemia adolescent and young adults compared to children, adults, and BCR::ABL1-positive acute lymphoblastic leukemia.

ELTS and EUTOS scores were highly significant in the adults p < 0.001; HR = 7; CI 3.29–14.89 and p = 0.001; HR = 3.4, CI 1.66–6.98, respectively.

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De novo CRG mutations significantly worsened the PFS in AYA ( p = 0.002; HR = 6.1, CI 1.98 – 18.75), while they showed a trend toward increased risk in adult patients, though not statistically significant ( p = 0.07; HR = 2.04, CI 0.95–4.36).

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