White Matter Anomaly Associated Cognitive Impairment During Systemic Inflammation Is Related to CX3CR1 Mediated Microglia-Node Interactions That Impacts the Conductive Function of Axons.

19 , 20 , 36 The areas under the N1 curves of CX3CR1 +/+ CCR2 −/− mice displayed a nearly significant downshift of I/O curves following LPS treatment ( Figure 2D , F 8, 153 = 60.37, p = 0.0787, n = 8), with a significant reduction in CAP amplitude at 0.40 ~ 0.50 mA stimulation points, compared to the saline littermates (2D, p < 0.01 at 0.40 and 0.45 mA points, t = 3.51, t = 3.06, df = 15; p < 0.05 at 0.05 mA point, t = 4.03, df = 15, n = 8).

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