Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis.

Arthritis Rheumatol · 2025 · PMC12209744 · PMID 39887650

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hedged sentences

0.2300

closest p · 4.6× alpha

0.2300

boldest claim

The sentences

did not reach statistical significanceP = 0.230not close (p > 0.1)

Conversely, when considering deaths attributed to scleroderma (n = 16), after adjusting for age, IFN score had a significant positive association with SSc mortality in its linear component (HR 2.83, 95% CI 1.18–6.75; P = 0.019), whereas the nonlinear component did not reach statistical significance ( P = 0.230).

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a trend toward significanceno p-value reported

7 Notably, we observed a numerically higher proportion of patients with low IFN score presenting an isolated ACA positivity (45% vs 33%) with a trend toward significance.

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