Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?

6 , 9 A recent clinical study also detected elevated NET debris (DNA:elastase and DNA:histone H3 complexes) in RA plasma, although this did not reach statistical significance or correlate with disease activity. 72 Our bioinformatics analyses identified a key role of miRNAs miR-182-5p, miR-183, and miR-96 in regulating RA neutrophil gene expression.

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