Human albumin infusion for reducing hyponatremia and circulatory dysfunction in liver cirrhosis: A meta-analysis update.

World J Hepatol · 2025 · PMC12210167 · PMID 40606931

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a favorable trendno p-value reported

Among efficacy measures, albumin was significantly more effective than the alternative treatments evaluated in resolving hyponatremia and PICD, whereas its effect on severe infection showed a favorable trend but was not significant.

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did not reach statistical significanceno p-value reported

Albumin use was significant in reducing odds of hyponatremia [odds ratio (OR) = 0.67; 95% confidence interval (95%CI) = 0.53-0.85] and PICD (OR = 0.38; 95%CI = 0.20-0.71), whereas the reduction in severe infection (OR = 0.55; 95%CI = 0.28-1.07) did not reach statistical significance.

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