Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Differences were considered statistically significant at p < 0.05 (*) and highly significant at p < 0.01 (**), p < 0.001 (***), p < 0.0001 (****).

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S1 a), our analysis revealed that most circRNAs predominantly increased with age in WT animals, while they showed a decreasing trend in SOD1G93A mice. circRNA levels tend to increase in skeletal muscle of SOD1G93A mice Next, the expression of the selected circRNAs was studied in quadriceps of SOD1G93A and WT mice throughout the disease course using muscle tissue derived from the same male mice as in the spinal cord.

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4 b), 11 host genes were significantly upregulated and one showed a trend toward significance ( Zfp609 ).

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Interestingly, an obvious trend was observed toward a gradual decrease of circRNA levels in spinal cord of SOD1G93A mice, which generally reached the largest fold change at the symptomatic and terminal stages of the disease.

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4 a), 10 host genes were significantly downregulated and one ( Samd4 ) exhibited a near-significant decrease.

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4 b), 11 host genes were significantly upregulated and one showed a trend toward significance ( Zfp609 ).

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