nominally significantp = 5.76×10 -2
TNM stage was found to influence the abundance of Fusobacterium in S1 samples (β = 0.610, 95% CI: 0.066 to 1.154, p = 2.80×10 -2 ) ( Supplementary Table 2 ), while CEA levels had a nominally significant association with the abundance of Holdemanella in S1 samples (β = -3.977, 95% CI: -8.161 to 0.20], p = 5.76×10 -2 ) ( Supplementary Table 4 ).