Barely Significant
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Multi-omics integration identifies key biomarkers in retinopathy of prematurity through 16S rRNA sequencing and metabolomics.

Front Microbiol · 2025 · PMC12213487 · PMID 40606147

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a decreasing trendno p-value reported
Alpha-diversity analysis revealed that while no statistically significant differences were found between the two subgroups on the Chao, Shannon, ACE, Simpson indices, a decreasing trend in alpha-diversity was observed in the probiotic group ( Supplementary Figure 2B ).

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However, these differences did not reach statistical significance. 3.6 Identification and functional analysis of DAMs in ROP samples at T2 time Because of the significant diversity of the intestinal flora at week 4 (T2), we further performed metabolomic analysis of the fecal samples at T2.

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