Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis.

Although the WT and KO ECRS groups exhibited an apparent increase in goblet cell numbers compared to both PBS groups, this difference did not reach statistical significance, indicating that goblet cell hyperplasia under ECRS conditions was not consistently altered by periostin deficiency ( Supplementary Figures S4A, B ).

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In HNFs, periostin expression showed an increasing trend following both IL-4 and IL-13 treatment, although only the IL-4 treated group reached statistical significance at day 2 ( P = 0.013, two-way ANOVA with Dunnett’s multiple comparisons test) ( Figure 2B ).

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