Barely Significant
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The effects of kratom <i>(Mitragyna speciosa)</i> on metabolic syndrome-related parameters: a systematic review and meta-analysis.

Front Pharmacol · 2025 · PMC12214432 · PMID 40606596

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a favorable trendno p-value reported
A favorable trend toward lower TC and FBS levels was observed in the kratom-consuming group compared to those with no or low consumption although the difference was not statistically significant.

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showed a trendno p-value reported
3.4.1 Total cholesterol (TC) The combined random-effect model results showed a trend towards a reduction in total cholesterol (TC) levels among kratom users compared to those with low or no kratom use (MD -0.207 mmol/L; 95% CI: −0.415, 0.002), with minimal evidence of heterogeneity (I 2 = 12.1%, P = 0.33; Figure 2A ).

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