Mild Chronic Colitis Exacerbates Intracerebral Inflammation in Mice with Parkinson's Disease Through LRRK2-Mediated Regulation of NF-κB Activation and Inhibition of Nrf2.

Additionally, a similar modeling approach used by Martinez et al revealed that striatal Iba-1 expression levels in MPTP+DSS mice showed an increasing trend compared to the MPTP group, which is consistent with the results of our study. 43 LRRK2 kinase activity has been identified as a marker of neuronal function and toxicity. 44 However, it is noteworthy that polymorphisms linked to an increased risk of developing PD and IBD have been identified in the coding and non-coding regions of the LRRK2 gene.

also in 63,971 other papers

Compared to the MPTP group, the DSS+MPTP group showed a trend towards worse performance in both distance and time in center zone without statistical significance.

also in 53,322 other papers