Histone lysine methyltransferases MLL3 and MLL4 direct gene expression to produce platelets efficiently.

We observed the expected depletion of platelets on day 1 and day 2 for both WT and PTIP KO mice; however, we also observed slower subsequent platelet regeneration in PTIP KO mice, albeit the difference did not reach statistical significance until day 4 (Fig. 2b ).

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