Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease.

Interestingly, probably due to the restrictions of creatinine-based eGFR in subjects with early-stage CKD or no CKD, both polynomial and linear regression models between sweat weight / sweat sodium concentration and eGFR did not reach statistical significance after exclusion of ESKD/HD patients, in which creatinine-based calculation cannot be meaningfully interpreted (Supplemental Figs. 3 , 4 ).

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