nominally significantP < 0.05
The following criteria were set to determine positive results: (1) consistent direction of estimates across the three methods (all estimates are either greater than 0 or less than 0) 32 ; (2) correction of results using the Bonferroni correction procedure to mitigate potential false-positive results due to multiple testing 28 ; A nominally significant threshold (0.05/N < P < 0.05, where N is the number of multiple tests) was considered suggestive evidence, while P < 0.05/N was considered significant association.