In the naïve mouse, compared to the hippocampus, the expression of Fn1 and Pecam1 was significantly higher in cortical microvessels, while Kdr , Cd34 , and Cd93 exhibited a clear trend of increased expression.
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Diminished angiogenic capacity in the hippocampus compared to the cortex indicates regional vulnerability.
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Our results demonstrated that, compared to the hippocampus, the genes expression levels of Fn1 and Pecam1 were significantly higher in the cortical microvessels ( P < 0.05), while the genes Kdr , Cd34 , and Cd93 showed a notable trend towards higher expression levels (Fig. 4 ).