An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling.

Embryonic myr-AKT-AAV1 treatment also showed a trend for amelioration of invasion volume under a setting of 20% FBS w/o HI albeit without a statistical significance ( P = 0.0906) (Supplementary Fig. 9H–K ), suggesting a partial efficacy of AKT1 transduction to alleviate the defects by COX-2 insufficiency and also its limitation to recover other unknown defects with FBS.

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With 20% FBS with or without HI, our system exhibited a significantly lower number of embryonic sustention at 48 h than that with the EXiM medium, with a decreasing trend of attachment efficiency at 24 h (Supplementary Fig. 9A and B ).

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