Viral characterization of the reassortants between canine influenza H3N2 and human pandemic (2009) H1N1 and avian H9N2 viruses in canine ex vivo tracheal explants.

On the other hand, H3N2-CIV/H9N2-G1H reassortants infected A549 cells showed a trend of increased cytokine and chemokine production as opposed to mock and H3N2-CIV infected cells, despite that production of IFN-β, ISG15, IL-6, IL-8, IP-10 and RANTES induced by the reassortants were consistently lower than that by H9N2-G1H.

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The reassortants had an overall trend of higher replication efficiency when compared with the parental strains.

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