Low-Dose Combinations With 3 or 4 Blood Pressure-Lowering Medications for the Treatment of Hypertension.

JACC Adv · 2025 · PMC12219345 · PMID 40554405

Europe PMC DOI

hedged sentences

0.1060

closest p · 2.1× alpha

0.1060

boldest claim

The sentences

showed a trendP = 0.106not close (p > 0.1)

Meta-regression showed a trend for greater DBP reduction with higher pretreatment DBP ( P = 0.106) ( Figure 2B ).

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borderline significantno p-value reported

Compared to monotherapy, LDC therapy was associated with a borderline significant increase in individuals reporting dizziness (7% vs 3%; RR: 2.62; 95% CI: 1.00-6.86) but no other adverse events including peripheral edema, headache, musculoskeletal pain, or serious adverse events ( Table 2 ).

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