Gender differences in drug-induced precocious puberty: a real-world analysis of adverse event reports from the FDA FAERS database (2004-2024).

Although the use of certain medications has a clear association with the onset of precocious puberty, there may be significant differences in drug responses between gender groups.

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In males using TESTOSTERONE, the early failure-type curve was also observed, while in females using the same drug, the β value was equal to or close to 1, and its 95% confidence interval included 1, indicating that the incidence of AEs did not show a significant trend over time, which aligns with the characteristics of a random failure-type curve.

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