Immunogenicity and innate immunity to high-dose and repeated vaccination of modified mRNA versus unmodified mRNA.

Mol Ther Nucleic Acids · 2025 · PMC12221724 · PMID 40612710

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did not reach statistical significanceno p-value reported

In contrast, although IL-7 exhibited a similar fold change pattern across groups in the RNA sequencing (RNA-seq) data, it did not reach statistical significance in the enrichment analysis ( Figure S3 B).

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a slight trendno p-value reported

We observed a slight trend toward lower levels of IL-7 and IFN-α in the groups receiving unmodified and high-dose modified mRNA vaccine, which may suggest potential induction of TLR tolerance.

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