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Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial.

Sci Rep · 2025 · PMC12222502 · PMID 40603444

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Among the multiple sleep dimensions, patients in the LAF & ESO group exhibited more remarkable improvements in subjective sleep quality, sleep disturbance, and used sleep medication, though these differences did not reach statistical significance (Supplementary Table 2 ).

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