Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation.

Additionally, while recipients with TT genotype in UGT1A4*3 had a significantly higher mean tacrolimus dose/weight ratio than those with GG or GT genotypes (0.10 [0.05, 0.14] versus 0.06 [0.04, 0.10] mg/kg/d, p = 0.037), the corresponding difference in C 0 /D did not reach statistical significance (72.2 [50.2, 128.5] versus 105.6 [59.3, 186.2] (ng/mL)/(mg/kg/d), p = 0.24).

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