Myeloid Neoplasms With Erythroid Predominance and Excess Blasts in Young Adults Exhibit Distinct Genetic Profiles.

In this population of young adults with AEML, the presence of UBTF ‐TD was associated with a decreased DFS compared to NPM1 ‐mutated patients and NPM1/UBTF ‐unmutated patients although it did not reach statistical significance (5y‐DFS: 15% [95% CI: 2.8%–80.4%], 58.2% [95% CI: 37.4%–90.5%] and 66.7% [95% CI: 46.6%–95.3%] respectively; p = 0.12) (Figure S2 ). 3.3 NPM1 ‐Mutated AEML Molecular Features Our cohort of AEML included 15 cases with NPM1 mutations, which represented the most frequent molecular lesion in young adults.

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