Adjusting for comparable covariates, among the mitochondrial-specific sites that were FDR-significant in the PROGRESS cohort, one was nominally significant in the replication cohort (cg17297328, mapping to SLC25A24 ) ( Supplemental Table S12 ).
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Newborn mitochondrial DNA copy number is associated with changes to DNA methylation that persist into childhood and are associated with cognitive development.
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