Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer.

Additionally, there was an increasing trend in the TMEscore from IE to IS to IA, with IA showing the highest TMEscore (both p < 2.2×10 −16 , Figure 2F ; p < 2.2×10 −16 , p < 2.2×10 −16 , and p = 3.6×10 −10 , respectively; Figure S2B , Supporting Information).

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Remarkably, a clear trend was observed across the three TME subtypes, with an apparent evolutionary order from IA to IS, and then to, i.e., This order can be rationalized by insights into the aging microenvironment and tissue damage repair processes [ 19 ] (Figure 3H–J ).

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