Sex-based immunological differences in multisystem inflammatory syndrome in children: potential role of T_R3-56 cells for pathogenesis, diagnosis, and therapy.

Although not statistically relevant due to the small sample size, an interesting trend emerges: among Group 1 patients with greater disease severity, males exhibited a higher mean percentage of T R3–56 cells (3.6 ± 2.2, mean ± SE) compared to females (0.8 ± 0.2).

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Although this trend did not reach statistical significance, it could suggest a potential attempt to negatively modulate immune response in MIS-C.

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