Selective identification of polyploid hepatocellular carcinomas with poor prognosis by artificial intelligence-based pathological image recognition.

As expected, both the median tumor nuclear area and the median nuclear major axis extracted by HEIP showed a highly significant correlation with the polyploidy score calculated by HIPT_unfrozen2, suggesting that HEIP accurately captured tumor nuclear morphology (Fig. 5d, e ).

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As expected, GD-positive HCC evaluated by genomic analysis showed a trend toward poor prognosis compared to GD-negative HCC, although the difference was weak and insignificant (Fig. 4b ).

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