Re-evaluation of neotame (E 961) as food additive.

Also, after 24 h exposure in the absence of metabolic activation, the frequency of binucleated cells with micronuclei was reported to be significantly elevated at all concentrations ( p < 0.05 for the lowest concentration tested; p < 0.001 all subsequent concentrations) with a significant trend test ( p < 0.001).

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