Navigating the blurred boundary: Neuropathologic changes versus clinical symptoms in Alzheimer's disease, and its consequences for research in genetics.

J Alzheimers Dis · 2025 · PMC12231839 · PMID 39956949

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a clear trendno p-value reported

Following the theoretical expectation that increasing the number of subjects may be the key to discover markers associated to AD, GWAS have been showing a clear trend to increase the number of analyzed subjects, the most recent including subjects whose AD status was established by proxy ( Figure 1A ).

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