In inflammatory conditions, the difference between diffuse PVNS synoviocytes and the other two did not reach statistical significance but the concentration of IL-6 remained higher than in localized PVNS and RA synoviocytes (453.1 ± 162.5 vs. 169.4 ± 43.3 ng/ml and 269.3 ± 20.6 ng/ml respectively; NS; Fig. 2 A).
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IFNγ production during cell interactions distinguishes localized from diffuse pigmented villonodular synovitis and rheumatoid arthritis.
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