Retention rate of TNF inhibitors versus IL-17 inhibitors in ankylosing spondylitis patients with prior biologics experience.

Arthritis Res Ther · 2025 · PMC12232199 · PMID 40615873

Europe PMC DOI

hedged sentences

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

did not reach statistical significanceP = 0.064so close (0.05 < p ≤ 0.1)

However, in multivariable Cox regression, the number of previous biologics (HR: 1.62, 95% CI: 1.17–2.23, P = 0.003) and BASDAI (HR: 1.3, 95% CI: 1.03–1.65, P = 0.030) were significantly associated with drug discontinuation, whereas the class of biologics did not reach statistical significance (HR: 2.11, 95% CI: 0.96–4.63, P = 0.064).

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borderline significanceno p-value reported

The class of biologics (HR: 2.11, 95% CI: 0.96–4.63, P = 0.064) showed only borderline significance.

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