Neuroprotective Effects of a Benzofuran-Containing Selenium in a Mouse Alzheimer's Disease Model: Molecular, Biochemical, and Behavioral Analyses.

Oxidative stress plays a critical role in neurodegeneration, and STZ administration led to a decrease in NRF2 expression [ F (2, 9) = 3.099, p = 0.0946] ( Figure H), suggesting an impaired antioxidant response. Although treatment with TFSeB increased NRF2 expression, this effect did not reach statistical significance.

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